The best time to trade in every single Madden is in the Free Agency Signing week one in the Offseason. This is when all the teams in the NFL are at their lowest amount of players because teams are getting ready for the Free Agency Signing period. This means the CPU will think they need a lot of players and show interest on players who are low overalls.
How to capitalize on this, even more, is to sign deals like what we have in our contract tips. You will sign guys to cheap no guaranteed contracts and trade them for gold at this time without any cap penalty and just soak up huge profits.