Each Madden has certain aspects to it, and if you pick up on them you can utilize them and win a lot of games. Remember, Madden was made by humans and humans tend to make mistakes. Electronic Arts (EA) will always try to make Madden as real as possible, but they are nowhere close yet. Utilize both of these aspects: the real aspects and the fake aspects.
The real aspect of Madden would be that players get tired. It does not matter if they have 99 stamina, they will eventually get tired. The best way to score on a high overall player with an average player would be to go against a tired high overall player. Furthermore, subbing TE’s with second or third string tackles when you know you are running will save energy for some of your guys while forcing the defense to use theirs. This is only a small sample, but this is the thought process you need to be thinking about. The majority of the time most people will not know if you subbed out a TE and the computer is not programmed to care.
The fake aspects of Madden are another thing to look for. One fake aspect would be being caught dead to rights and still juke out of it by simply timing it correctly. Another aspect of Madden being unrealistic would be they cannot catch on. What we mean is if you run a play that works every time, no matter the coverage, they still will not predict where you are going even though it is obvious. Also, if you are playing a user this may cause them to have to try and manually cover your player, which almost never works. They may also try and double cover that player, which means they left another area on the field exposed for you to capitalize on. If they go back to their regular coverage after you capitalized on them running double coverage or trying to manually cover your go-to guy, just simply go back to the same play you were running that the computer/user could not stop.